Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials

Authors

  • Nadia A. Betti materials engineering department/university of technology/ iraq
  • Redha Ib. Hussain
  • Sahar Ab. Kadhem

DOI:

https://doi.org/10.30684/etj.v38i3B.706

Abstract

New derivatives of pyrrolidine-2-one have been synthesized through lactamization of γ –butyrolactone (GBL) by hydrazine hydrate (80%), ethylene diamine and ethanol amine to afford compounds (1-aminopyrrolidin-2-one), (1-(2-aminoethyl)pyrrolidine-2-one) and (1-(2-hydroxyethyl)pyrrolidine-2-one), respectively. Compound (1-aminopyrrolidin-2-one) underwent several reactions to synthesize the rest of these derivatives. All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra. The biological activities of these derivatives were evaluated against Escherichia coli and Staphylococcus aureus. Many of these derivatives showed moderate biological activity against one or both kind of bacteria in comparison to amoxicillin and some showed no biological activity at all.

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Published

2020-12-25

How to Cite

Betti, N. A. ., Hussain , R. I. ., & Kadhem , S. A. . (2020). Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials. Engineering and Technology Journal, 38(3B), 128-141. https://doi.org/10.30684/etj.v38i3B.706